Immunotherapy is a modern approach to cancer treatment that uses a patient's own immune system to help fight tumors. It has made an incredible impact on treating cancers in many different organ ...

Bile acids are essential molecules the liver produces that play a critical role in digestion. They help us absorb fat-soluble vitamins and cholesterol from our food. However, bile acids can become a ...

A new study reveals how a critical imbalance in bile acids—the substances made by the liver that help digest fats—can trigger liver diseases, including hepatocellular carcinoma (HCC), the most common ...

(A) The classic bile acid synthesis pathway: cholesterol 7α-hydroxylase (CYP7A1) converts cholesterol to 7α-hydroxycholesterol (7α-HOC). The sterol 12α-hydroxylase (CYP8B1) converts the intermediate ...

Immunotherapy is a modern approach to cancer treatment that uses a patient's own immune system to help fight tumors. It has made an incredible impact on treating cancers in many different organ ...

Immunotherapy is a treatment that helps the body’s own immune system fight cancer. It has worked well for several cancers ...

Rectify Pharma is using its ABCs to treat PSC. Three years after raising $100 million in series A funds, the Atlas Venture-backed biotech has chosen a lead drug candidate: the small molecule RTY-694, ...

Bile acids are essential to digestion, by acting like a kind of detergent that breaks up fat molecules. Fat doesn't dissolve in water, but our digestive system is full of water, so the fat we consume ...

Salk Institute scientists discovered that bile acids in the liver can weaken immune cell function, making immunotherapy less effective against liver cancer. They pinpointed specific bile acids that ...