Molecular Dynamics Simulations are grounded in classical mechanics, particularly Newton’s laws of motion, to predict how particles move within a system. The force acting on each atom is calculated ...

Using cryogenic mass spectrometry, scientists from the University of Nottingham’s School of Pharmacy and their collaborators elsewhere developed an approach for depth profiling frozen lipid ...

Malvern Panalytical’s recent peer-reviewed publication, Tailoring Lipid Nanoparticle Dimensions Through Manufacturing Processes, published in RSC Pharmaceutics, features both the NanoSight Pro ...

Lipid nanoparticles consist of spherical vesicles made of ionizable lipids with a positive charge at a low pH level, while being neutral at a physiological pH. Such a characteristic enables RNA ...

Scientists from the University of Pennsylvania have developed an ideal “recipe” for ionizable lipids, which are essential components of lipid nanoparticles (LNPs), the molecules that underlie the ...

Scientists have discovered that the internal shape of tiny drug-delivery particles—called lipid nanoparticles—has a big impact on how well our cells absorb them, paving the way to more efficient ...

Engineers have cooked up a new way to improve mRNA delivery, developing an optimal 'recipe' for ionizable lipids -- key ingredients in lipid nanoparticles (LNPs), the molecules behind the COVID-19 ...

A recent perspective article published in the journal Nature Reviews Drug Discovery discussed the evolution of lipid nanoparticles (LNPs) for nucleic acid delivery. The authors, Pieter Cullis, ...