Multifactorial diseases, such as coronary artery disease, can be as complex as their name suggests. How much can we hope to understand about diseases with such variation in inheritance? Aa Aa Aa ...

. For about a century, the argument for focusing on rare Mendelian disorders was as follows: Mendelian phenotypes will reveal genes involved in common multifactorial traits, metabolic pathways ...

In an age when the majority of monogenic human disease genes have been identified, one of the challenges for the coming generation of human geneticists will be to resolve complex polygenic and ...