Directed Evolution (DE) is a method developed by Nobel laureate Frances Arnold to improve protein fitness for specific applications. However, DE can be less efficient when mutations show epistatic ...

Confinement of enzymes in protein nanocompartments represents a potentially powerful strategy for controlling catalytic activity in cells. By using a simple electrostatically based tagging system for ...

A research team maps the key tasks that define modern enzyme engineering—function annotation, structure modeling, and property prediction—and explain how AI methods now accelerate each step, from ...

An artist’s depiction of an artificially evolved enzyme breaking a silicon-carbon bond. [Caltech/Dow] For the first time, scientists have engineered an enzyme that can break the stubborn man-made ...

Protein design is crucial for the treatment of human diseases, but traditional protein design methods have some limitations. Site-directed mutagenesis is highly dependent on the physiological ...

A research team has unveiled a breakthrough in understanding how specific genetic sequences, known as pseudogenes, evolve. Rice University's Peter Wolynes and his research team have unveiled a ...

A new platform combines rational protein design with continuous evolution to discover functional molecules more efficiently. In medicine and biotechnology, the ability to evolve proteins with new or ...

Stereoview of mutation loci in mPlum based on the crystal structure of DsRed. Red: the RFP chromophore; yellow: emission shift mutations; gray: neutral mutations. A team of researchers at the ...