XPC protein acts as a sensor to detect various abnormalities in the DNA structure. The faithful repair of DNA is ensured by using the basal transcription factor TFIIH and XPA protein to verify the ...

NER is a critical pathway that removes cyclobutane pyrimidine dimers (CPDs), a common form of UV-induced damage. Given the vast number of DNA base pairs, the speed and efficiency of damage detection ...

Our genomic DNA is continuously damaged by endogenous factors such as reactive oxygen species, and also by environmental factors such as ultraviolet light, radiation, and chemicals. Failure to repair ...